Research group Karsten Haupt


Molecular Imprinting Technology
Polymer with theophylline-specific binding site

    Short CV Karsten Haupt
    The team
    Research : Molecular Imprinting / Other
    Other activities
    For additional information...
    List of publications


Short CV Karsten Haupt
Docent competence (habilitation)
Lund University, Sweden
PhD in biochemical technology University of Technology of  Compiègne, France
Diploma in Biochemistry University of Leipzig, Germany

Since Sept 2003
Professor for Nanobiotechnology at the Compiègne University of Technology, France

Since April 2000 Guest Docent at Lund University, Sweden

Sept 99 - Aug 2003
Maître de conférences (research lecturer) at University of Paris XII, France. Bioanalytical chemistry and biomimetic polymers
Apr 98 - Aug 99 Research fellow, Institut National de la Transfusion Sanguine, INSERM U76, Paris, France. Structure-function relationships of and interactions between erythrocyte membrane proteins
Nov 95 - Apr 97 Post-doc at Lund University, Sweden, Department of Pure and Applied Biochemistry. Molecular  imprinting and applications in separation and analysis
Oct 94 - Oct 95 Research lecturer at  University of Technology of  Compiègne, Department of Bioengineering. Affinity capillary electrophoresis, affinity membrane technology
Mar 91 - Nov 94 PhD student, Université de Technologie de Compiègne, France, Department of Bioengineering. PhD thesis on "The Role of Histidine in Protein Recognition: Study about Histidine in Synthetic Polymers and in Proteins"
Jan 90 - Feb 91 Diploma in Biochemistry at University of Leipzig, Germany. "Investigation of induction  and substrate specificity of Aldehyde dehydrogenase from Pseudomonas putida"

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Molecular Imprinting, Assays, Sensors

Salah Salman, Karsten Haupt, Kumaran Ramanathan and Bengt Danielsson (1997)
Thermometric sensing of fluoride by adsorption on ceramic hydroxyapatite using flow injection analysis
Anal. Commun. 34, 329-332

Karsten Haupt (1998)
Non-covalent molecular imprinting of the herbicide 2,4-dichlorophenoxyacetic acid in the presence of polar protic solvents
In Bartsch, R.A. and Maeda, M. (Eds.) "Molecular and Ionic Recognition with Imprinted Polymers", ACS Symposium Series, Vol. 703, 135-142

REVIEW    Klaus Mosbach, Karsten Haupt, Xiao-Chuan Liu, Peter A.G. Cormack and Olof Ramström (1998)
Molecular Imprinting: Status Artis et Quo Vadere?
In Bartsch, R.A. and Maeda, M. (Eds.) "Molecular and Ionic Recognition with Imprinted Polymers", ACS Symposium Series, Vol. 703, 29-48

REVIEW    Klaus Mosbach and Karsten Haupt (1998)
Some new developments and challenges in non-covalent molecular imprinting technology
J. Molec. Recogn. 11, 62-68

Karsten Haupt, Anatoli Dzgoev and Klaus Mosbach (1998)
Assay system for the herbicide 2,4-dichlorophenoxyacetic acid using a molecularly imprinted polymer as the artificial recognition element
Anal. Chem. 70, 628-631

Karsten Haupt, Andrew Mayes and Klaus Mosbach (1998)
Herbicide assay using an imprinted polymer-based system analogous to competitive fluoroimmunoassays
Anal. Chem. 70, 3936-3939

REVIEW    Karsten Haupt and Klaus Mosbach (1998)
Plastic antibodies: Development and applications
Trends Biotechnol. 16, 468-475

Anatoli Dzgoev and Karsten Haupt (1999)
Enantioselective molecularly imprinted polymer membranes
Chirality 11, 465-469

Karsten Haupt (1999)
Molecularly imprinted sorbent assays and the use of non-related probes
React. Funct. Polym. 41, 125-131

Ecevit Yilmaz, Klaus Mosbach and Karsten Haupt (1999)
Influence of functional and cross-linking monomers and the amount of template on the performance of molecularly  imprinted polymers in binding assays
Anal. Commun. 36, 167-170

REVIEW    Karsten Haupt and Klaus Mosbach (1999)
Imprinted polymers in chemical and biological sensing
Biochem. Soc. T.  27, 344-350

Silke Kröger, Anthony Turner, Klaus Mosbach and Karsten Haupt (1999)
Imprinted polymer-based detection of herbicides using differential pulse voltammetry on screen-printed electrodes
Anal. Chem. 71, 3698-3702

Michael Jakusch, Markus Janotta, Boris Mizaikoff, Klaus Mosbach and Karsten Haupt (1999)
Molecularly imprinted polymers and infrared evanescent wave spectroscopy. A chemical sensors approach
Anal. Chem. 71, 4786-4791

Karsten Haupt, Krzysztof Noworyta and Wlodzimierz Kutner (1999)
Imprinted polymer-based enantioselective acoustic sensor using a quartz crystal microbalance
Anal. Commun.36, 391-393

Ioana Surugiu, Lei Ye, Ecevit Yilmaz, Anatoli Dzgoev, Bengt Danielsson, Klaus Mosbach and Karsten Haupt (2000)
An enzyme-linked molecularly imprinted sorbent assay. Analyst 125, 13-16

Ecevit Yilmaz, Karsten Haupt and Klaus Mosbach (2000)
The use of immobilized templates ? A new approach in molecular imprinting. Angew. Chem. Int. Ed. Engl. 39, 2115-2118

REVIEW    Karsten Haupt and Klaus Mosbach (2000)
Molecularly imprinted polymers and their use in biomimetic sensors. Chem. Rev. 100, 2495-2504

Oliver Bruggemann , Karsten Haupt, Lei Ye, Ecevit Yilmaz, Klaus Mosbach (2000)
New configurations and applications of molecularly imprinted polymers. J. Chromatogr. A, 889, 15-24.

Ioana Surugiu, Bengt Danielsson, Lei Ye, Klaus Mosbach and Karsten Haupt (2001)
Chemiluminescence imaging ELISA using an imprinted polymer as the recognition element instead of an antibody. Anal. Chem. 73, 487-491.

REVIEW    Karsten Haupt (2001)
Molecularly imprinted polymers in analytical chemistry. Analyst 126, 747-756.

Ioana Surugiu, Juraj Svitel, Lei Ye, Karsten Haupt and Bengt Danielsson (2001)
Development of a flow-injection capillary chemiluminescent ELISA using an imprinted polymer instead of the antibody. Anal. Chem. 73, 4388-4392.

Lei Ye, Ioana Surugiu and Karsten Haupt (2002)
Scintillation proximity assay using molecularly imprinted microspheres. Anal. Chem. 59-964.

NEWS & VIEWS    Karsten Haupt (2002)
Creating a good impression. Nature Biotechnol. 20, 884-885.

Qing-Zhi Zhu, Karsten Haupt , Dietmar Knopp and Reinhard Niessner (2002)
A molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides. Anal. Chim. Acta 468, 217-227.

Yihua Yu, Lei Ye, Karsten Haupt and Klaus Mosbach (2002)
Formation of a class of enzyme inhibitors, including a chiral compound, using imprinted polymers or biomolecules as molecular-scale reaction vessels. Angewandte Chemie International Edition 41, 4459-4463.

REVIEW    Karsten Haupt (2003)
Imprinted polymers - Tailor-made mimics of antibodies and receptors. Chem. Commun.
2, 171-178

REVIEW    Karsten Haupt (2003)
Imprinted polymers - The next generation. Anal. Chem. 75, 376A-383A.

Ronald H. Schmidt, Klaus Mosbach and Karsten Haupt (2004)
A simple method for spin coating molecularly imprinted polymer films of controlled thickness and porosity. Adv. Mater. 16, 719-722.

REVIEW    Lei Ye and Karsten Haupt (2004)
Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery. Anal. Bioanal. Chem. 378, 1887–1897.

Yong-Ho Shim, Ecevit Yilmaz, Solange Lavielle and Karsten Haupt (2004)
Chiral recognition and separation of beta-2-amino acids using non-covalently molecularly imprinted polymers. Analyst 129, 1211-1215.

Ronald H. Schmidt, Karsten Haupt (2005)
Molecularly imprinted polymer films with binding properties enhanced by the reaction-induced phase separation of a sacrificial polymeric porogen. Chem. Mater.  17, 1007-1016.

Ronald H. Schmidt, Anne-Sophie Belmont and Karsten Haupt (2005)
Porogen formulations for obtaining molecularly imprinted polymers with optimized binding properties. Analytica Chimica Acta 542, 118-124.

Elena Gavioli, Norbert M. Maier, Karsten Haupt, Klaus Mosbach, Wolfgang Lindner (2005)
Analyte templating: Enhancing the enantioselectivity of chiral selectors upon incorporation into organic polymer environments. Analytical Chemistry  77, 5009-5018.

Anja Gräfe, Karsten Haupt, Gerhard J. Mohr (2006)
Optical sensor materials for the detection of amines in organic solvents. Analytica Chimica Acta 565, 42-47.

REVIEW    Valérie Pichon Karsten Haupt (2006)
Affinity Separations on molecularly imprinted polymers with special emphasis on solid-phase extraction. Journal of Liquid Chromatography 29, 989–1023.

Claire E. Hunt, Pamela Pasetto, Richard J. Ansell and Karsten Haupt (2006)
A fluorescence polarisation molecular imprint sorbent assay for 2,4-D : A non-separation pseudoimmunoassay. Chemical Communications 1754-1756.

Fernando Siñeriz, Yasunori Ikeda, Emmanuel Petit, Laurent Bultel, Karsten Haupt, José Kovensky, Dulce Papy-Garcia (2007)
Towards an alternative for specific recognition of sulfated sugars. Preparation of highly specific molecular imprinted polymers. Tetrahedron 63, 157-162.

Anne-Sophie Belmont, Stefanie Jaeger, Dietmar Knopp, Reinhard Niessner, Guenter Gauglitz and Karsten Haupt (2007)
Molecularly imprinted polymer films for reflectometric interference spectroscopic sensors. Biosensors&Bioelectronics 22, 3267-3272.

Anne-Sophie Belmont, Mordechai Sokuler, Karsten Haupt, Levi A. Gheber (2007)
Direct writing of molecularly imprinted micro and nanostructures using a nanofountain pen. Applied Physics Letters 90, 193101.

Fanny Vandevelde, Thierry Leichle, Cédric Ayela, Christian Bergaud, Liviu Nicu, Karsten Haupt (2007)
Direct patterning of molecularly-imprinted microdot arrays for sensors and biochips. Langmuir 23, 6490-6493.

Fanny Vandevelde, Anne-Sophie Belmont, Jacques Pantigny, Karsten Haupt (2007)
Hierarchically nanostructured polymer films based on molecularly imprinted surface-bound nanofilaments. Advanced Materials 19, 3717-3720.

Claire Rossi, Karsten Haupt (2007)
Application of the Doehlert experimental design to molecularly imprinted polymers: Surface response optimization of specific template recognition as a function of the type and degree of cross-linking. Analytical & Bioanalytical Chemistry 389, 455-460.

   Cédric Ayela, Fanny Vandevelde, Denis Lagrange, Karsten Haupt, Liviu Nicu (2007)
Combining resonant piezoelectric micromembranes with molecularly imprinted polymers. Angewandte Chemie International Edition 46, 9271-9274.

   Bernadette Tse Sum Bui, Anne-Sophie Belmont, Hilda Witters, Karsten Haupt (2008)
Molecular recognition of endocrine disruptors by synthetic and natural 17b-estradiol receptors: a comparative study. Analytical & Bioanalytical Chemistry 390, 2081-2088.

   Bérengère Claude, Philippe Morin, Michel Lafosse, Anne-Sophie Belmont, Karsten Haupt (2008)
Molecularly imprinted polymer for a triterpene acid and its application to solid-phase extraction of a plant extract. Talanta 75, 344-350.

  Fanny Vandevelde, Jacques Pantigny, Isabelle Pezron, Levi Gheber and Karsten Haupt (2008)
Nanostructured molecularly imprinted polymer films as synthetic recognition layers. International Journal of Nanotechnology (in press).

Affinity chromatography and membranes

Karsten Haupt and M.A. Vijayalakshmi (1993)
Interaction of catechol-2,3-dioxygenase of Pseudomonas putida with immobilized histidine and histamine
J. Chromatogr. 644, 289-297

Sonia M.A. Bueno, Karsten Haupt and M.A. Vijayalakshmi (1995)
Separation of immunoglobulin G from human serum by pseudobioaffinity chromatography using immobilized L-histidine in hollow fiber membranes
J. Chromatogr. 667, 57-67

Sonia M.A. Bueno, Karsten Haupt and M.A. Vijayalakshmi (1995)
In vitro-removal of human immunoglobulin G by pseudobiospecific affinity membrane filtration in large scale. A preliminary report
Int. J. Artif. Organs 18, 392-398

Karsten Haupt, Sonia M.A. Bueno and M.A. Vijayalakshmi (1995)
Interaction of human immunoglobulin G with L-histidine immobilized onto poly(ethylene vinyl alcohol) hollow fiber membranes
J. Chromatogr. 674, 13-21

Sonia M.A. Bueno, Cécile Legallais, Karsten Haupt and M.A. Vijayalakshmi (1996)
Experimental kinetic aspects of hollow-fiber membrane-based pseudobioaffinity filtration : Process for IgG separation from human plasma
J. Membrane Sci. 117, 45-56

Cécile Legallais, F.Birger Anspach, Sonia M.A. Bueno, Dagmar Petsch, Karsten Haupt and M.A. Vijayalakshmi (1997)
Strategies for the depyrogenation of contaminated immunoglobulin G solutions by histidine-immobilized hollow fiber membrane
J. Chromatogr. 691, 33-41

Daniella Bianchi, Olivier Bertrand, Karsten  Haupt and Nereida  Coello (2001)
Effect of gluconic acid as a secondary carbon source on non-growing L-lysine producers cells of Corynebacterium glutamicum - Purification and properties of 6-phosphogluconate dehydrogenase.
Enz. Microb. Technol. 28, 754-759.

Electrophoresis and CE

Karsten Haupt, François Roy and M.A. Vijayalakshmi (1996)
Immobilized metal chelate affinity capillary electrophoresis of proteins - a model for affinity capillary electrophoresis using soluble polymer-supported ligands
Anal. Biochem. 234, 149-154

Won-Ok Baek, Karsten Haupt, Carole Colin and M.A. Vijayalakshmi (1996)
Immobilized metal ion affinity gel electrophoresis: Quantification of protein affinity to transition metal chelates
Electrophoresis 17, 489-492

Yannick Boulis, Colette Richet, Karsten Haupt, Sylviane Hennebicq, Benoit Soudan, Daniel Tetaert, Pierre Degand and M.A. Vijayalakshmi (1998)
Improved capillary electrophoretic separation of glycosylated oligopeptides through addition of poly(vinyl alcohol), and analysis by electrospray mass spectrometry
J. Chromatogr. 805, 285-293

Book chapters

Peter A. G. Cormack, Karsten Haupt and Klaus Mosbach
Affinity separation: Imprinted polymer technologies. In: Encyclopaedia of Separation Science, Academic Press, 2000

Karsten Haupt and Sonia M.A. Bueno
Affinity membranes. In: Encyclopaedia of Separation Science, Academic Press, 2000

Peter A. G. Cormack, Karsten Haupt
Molecular imprints for solid-phase extraction. In: Encyclopaedia of Separation Science, Academic Press, 2000

Ecevit Yilmaz, Lei Ye, Karsten Haupt and Klaus Mosbach
The use of imprinted polymers as recognition elements in biosensors and binding assays. In Z. Liron, A. Bromberg and M. Fisher (Eds.) "Novel Approaches in Biosensors and Rapid Diagnostic Assays", Kluwer Academic/Plenum Press, New York, 2001, pp. 193-209.

Karsten Haupt, Peter A.G. Cormack and Klaus Mosbach
Molecularly imprinted stationary phases for affinity separation. In: M.A. Vijayalakshmi (Ed.) "Theory and Practise of Biochromatography", Taylor and Francis, London, 2002, pp. 419-431.

Karsten Haupt
Molecularly imprinted polymers as recognition elements in sensors: Mass and electrochemical sensors. In "Molecularly Imprinted Materials: Science and Technology", O. Ramström, Mingdi Yan, eds., Marcel Dekker Inc., New York, 2004, pp.

Karsten Haupt
Molecularly imprinted polymers : Artificial receptors for affinity separations. In "Handbook of Affinity Chromatography", David Hage, ed., Marcel Dekker Inc., New York, 2004, pp. 824-837.

Karsten Haupt
Molecularly imprinted polymers as recognition elements in sensors. In "Springer Series on Chemical Sensors and Biosensors, Volume 2 (Ultrathin Electrochemical Chemo and Biosensors)", Wladimir Mirsky and Otto Wolfbeis, eds., Springer Verlag Hamburg, 2004, pp. 23-39.

   Karsten Haupt and Anne-Sophie Belmont
Molecularly Imprinted Polymers as Recognition Elements in Sensors. In "Handbook of Biosensors and Biochips" Robert S. Marks, David C. Cullen, Isao Karube, Christopher R. Lowe and Howard H. Weetall, eds., John Wiley & Sons, Ltd. 2007, ISBN 978-0-470-01905-4.



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Main research interests

Molecular imprinting technology and biomimetic polymers
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Our activities in the area

  Rational design and optimisation of imprinted polymers

    Molecular imprints in nanostructured materials

   Sensors based on imprinted polymers
        Electrochemical sensors
        Acoustic sensors (Quartz crystal microbalance)
        Optical sensors (Infrared, SPR, optical interferometry, instrument-free sensors)

  Immuno-type binding assays based on imprinted polymers
        Fluorescence assays
        Enzyme-linked assays (chemiluminescence and colorimetric)
        High-throughput imaging formats
        Flow injection capillary assays
        Homogeneous assays

  Molecularly imprinted stationary phases for separation
        (Enantioselective) membranes
        Solid-phase extraction matrices
        Capillary electrophoresis


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Other research interests

Affinity capillary electrophoresis

General principle of capillary electrophoresis


Measurement of molecular interactions


                                    Separation and quantitation in one operation
                                    In solution
                                    Low sample consumption
                                    In general no labelling required

Affinity membranes for protein separation


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Other activities

Co-founder and scientific consultant of PolyIntell, a French start-up company working on intelligent, functional polymers, including hydrogels and molecularly imprinted polymers.

In 2004, PolyIntell was one of the winners of the Contest of Innovative and Technological Companies of the French Ministry of Research&Technology and the ESF, and was awarded the third Special Prize of the jury.
We are supported by ANVAR, the incubator Acceval and the Region of Upper-Normandy.

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The team

alien alien alien alien alien alien alien alien alien Jacques
Aude Cordin
(Assistant professor)
Bernadette Tse Sum Bui
(Research engineer)
Frank Pithan (Post-doc)
Julia Lessant
(PhD student)
Fanny Vandevelde
(PhD student)
Magali Bartkowski
(PhD student)
Arnaud Cutivet
(PhD student)
Ana Linares
(PhD student
Marc Bompart
(PhD student)
Jacques Pantigny
(Research technicien)

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Former co-workers


Klaus Mosbach
Ron Schmidt
Ecevit Yilmaz
(PhD student)
Anne-Sophie Belmont
(PhD student)
Lei Ye

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   First of all, what would I have done without these guys!
   We are part of the EU-funded research project NASCENT : Sensors based on imprinted polymers
   On combining molecularly imprinted materials with nanotechnology we are working with

 Dr. Levi A. Gheber
 Ben-Gurion University of the Negev, Beer-Sheva, Israel

 Dr. Yannick de Wilde  ESPCI Paris, France
   On imprinted polymer-based sensors we are working together with
     Prof. Wlodzimierz Kutner  Polish Academy of Sciences, Warsaw, Poland

 Dr. Gerhard Mohr  University of Jena, Germany

 Dr. Liviu Nicu
 CNRS (LAAS) Toulouse, France

 Prof. Karl-Heinz Feller
 Fachhochschule Jena, Germany
   Other collaborations related to molecular imprinting
     Dr. Andrew Mayes  University of East Anglia, Norwich, UK

 Dr. Kenneth Wärnmark
 Lund University, Sweden

 Dr. Richard Ansell
 University of Leeds, UK

 Prof. Azmi Telefoncu
 Ege University, Izmir, Turkey


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For additional information contact:

Karsten Haupt



Compiègne University of Technology
Department of Bioengineering
BP 20529
60205 Compiègne Cedex, FRANCE

Phone:       +33-3-44234455
Fax:            +33-3-44203910

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The Society of Molecular Imprinting homepage

with the famous literature database!

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